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Dr. Karl Fath

Assistant Professor

Ph.D.(Case Western Reserve University)

Office: NSB E -122 Tel: (718) 997- 3424

Laboratory: NSB E-141 Tel. (718) 997-3157  

E-mail: karl.fath @ qc.cuny.edu

 

Research interests:

My research is directed toward elucidation of the roles of the cytoskeleton in the formation and maintenance of cell polarity. Not only is the cytoskeleton a scaffold crucial to cell shape, it also serves as the tracks or highways upon which cell components are delivered to their correct cellular destinations. The constituents of the apical cytoskeleton and plasma membrane are important in the physiology of polarized intestinal epithelial cells. I have found that myosin-I, a nonmuscle actin-based motor, and dynein, a microtubule-based motor, are bound to Golgi-derived vesicles and may be important in the targeting and delivery to the apical plasma membrane domain. The mistargeting of plasma membrane proteins can cause illnesses such as microvillus inclusion disease and polycystic kidney disease, therefore, an understanding of delivery mechanisms may provide therapeutic tools.

A-549 (human epithelial-like cell line) cells double-labeled for polymerized actin (red) and the coatomer protein beta-COP (green), which is involved in membrane movement along the biosynthetic pathway.

Selected Publications:

 

Spear, R.L., R. Tamayev, K.R. Fath and I.A. Banerjee. 2007. Templated growth of calcium phosphate on tyrosine derived microtubules and their biocompatibility. Colloids Surf. B: Biointerfaces; in press.

K.R. Fath. 2006. Roles of the actin cytoskeleton and myosins in the endomembrane system. In Advances in Molecular and Cell Biology. E. Bittar, editor. Elsevier. 37:119-134.

K.R. Fath. 2005. Characterization of myosin-II binding to Golgi stacks in vitro. Cell Motil. Cytoskeleton, 60:222-235.

Boëda B, El-Amraoui A, Bahloul A, Goodyear R, Daviet L, Blanchard S, Perfettini I, Fath K.R., Shorte S, Reiners J, Houdusse A, Legrain P, Wolfrum U, Richardson G, Petit C. 2002. Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. EMBO J., 21:6689-6699.

Stow, J.L., K.R. Fath, and D.R. Burgess. 1998. Budding roles for myosin II on the Golgi. Trends in Cell Biology, 8:138 141.

Fath, K.R., G.M. Trimbur and D.R. Burgess. 1997. Molecular motors and a spectrin matrix associate with Golgi membranes in vitro. J. Cell Biol., 139:1169­1181.; VIEW DOCUMENT

Ikonen, E., J.B. de Almeida, K.R. Fath, D.R. Burgess, K. Ashman, K. Simons and J.L. Stow. 1997. Myosin II is associated with Golgi membranes: identification of p200 as nonmuscle myosin II on Golgi derived vesicles. J. Cell Sci., 110:2155 2164. VIEW DOCUMENT

Fath, K.R. and D.R. Burgess. 1996. Role of the cytoskeleton and molecular motors in transport between the Golgi complex and plasma membrane In Current Topics in Membranes. W. James Nelson, editor. Academic Press/San Diego, CA. 43:53 71.

Fath K.R., Trimbur GM, Burgess DR. 1994. Molecular motors are differentially distributed on Golgi membranes from polarized epithelial cells. J Cell Biol., 126(3):661-75. VIEW DOCUMENT

Fath K.R., Burgess DR. 1993. Golgi-derived vesicles from developing epithelial cells bind actin filaments and possess myosin-I as a cytoplasmically oriented peripheral membrane protein. J Cell Biol., 120(1):117-27. VIEW DOCUMENT

List of Publications from PubMed

 
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